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Bupropion stimulates POMC neurons in the hypothalamus to reduce appetite, but the body has a natural feedback loop that can dampen this effect over time
If youve been losing weight initially and then stopped to see progress, this means you may need fewer calories for your current lifestyle, and your level of physical activity is no longer enough for you to burn fat
Newlin says that the combination of low-calorie intake and gastrointestinal side effects can add up to low nutrient levels
This suggests that estradiol may increase thermogenesis by the inhibiting AMPK at the VMH nucleus of the hypothalamus
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