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Interestingly, 2-HG can be derived also from the promiscuous activity of some key metabolic enzymes, including malate dehydrogenase (MDH), lactate dehydrogenase (LDH) [25], and phosphoglycerate dehydrogenase (PHGDH) [26], and can accumulate in cancer cells in both its enantiomeric forms (i.e., D- and L-2HG)

[Evaluation of efficacy of propionyl-L-carnitine in chronic oral administration on cardiac muscle efficiency, on tolerance to exercise and on life quality of patients with chronic cardiac failure

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Manzel A, Muller DN, Hafler DA, Erdman SE, Linker RA, Kleinewietfeld M (2014) Role of Western diet in inflammatory autoimmune diseases