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Blood levels take about four weeks to settle after a step. The stomach-slowing effect that drives early nausea builds and then adapts over roughly the same window. And gut symptoms cluster at the first dose and at each increase, then ease with time on a held dose. The label waits for the last step to settle before adding the next
Those with pre-existing cardiac conditions or on medications affecting potassium levels may require closer monitoring
Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib
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