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Both GLP-1 and its agonists (GLP-1RAs) have been identified for suppressing appetite, slowing gastric emptying time, and inducing fullness and satiety, thereby reducing caloric intake under ad libitum feeding conditions (139141)

In older adults, lifestyle modifications remain a significant challenge [11, 20], and the increasing burden of NCDs further underscores the strategic role of pharmacotherapy as part of a comprehensive strategy of the obesity management

A stall at week 8 or 12 is almost certainly not a true plateau

Niitsu Y, Sato Y, Takanashi K et al (2020) A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations