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In girls with TS, p53 signaling was associated with carriage of the G allele of the rs2069502 CDK4 SNP (including a +1.5-fold increase in MDM2 expression, implying a repression of P53 function, 27 and a +1.5-fold increase in ATM expression, implying that DNA damage increased activation of P53
A thyroid function test helps evaluate T3 and T4 levels as well as thyroid-stimulating immunoglobulin (TSI) to determine whether autoimmune Graves disease is present
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Mechanistically, TMP suppressed CM-triggered activation of the CCL2/CCR2 axis, mitigated renal OS and irregular mitochondrial dynamics, and modulated mitophagy in renal tubular cells
