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For example, phentermine may cause cardiovascular issues like pulmonary hypertension, rapid heart rate, and heart failure
Staplin N, Roddick AJ, Neuen BL et al (2025) Effects of sodium glucose cotransporter 2 inhibitors by diabetes status and level of albuminuria: a meta-analysis
Fat mass percentage results from a 2023 ADA comparative metabolic analysis show a close race at the fat mass level: retatrutide 17.5% fat mass, tirzepatide 17.2%, semaglutide 14.3% (all Phase 2, percentage of fat mass, not total body weight)
Tirzepatide's dual-agonist profile is documented across the SURPASS clinical-trial programme (e.g
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