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A 6-year study of 2,596 adults aged 60 and older found that people starting with 4 or more chronic diseases had lower serum total glutathione than those with none (3.3 vs 3.6 micromol/L, a unit for very small concentrations in blood)
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Histone H2A monoubiquitination and Polycomb repression: The missing pieces of the puzzle
Consistent with these insights, it has been reported that alpha-ketoglutaric acid (KG), produced from isocitrate catalyzed by isocitrate dehydrogenase (IDH), and its downstream metabolites including succinic acid, fumaric acid, and malic acid, can displace the function of glutamine in the accumulation of lipid ROS and cystine starvation induced or system Xc inhibition induced ferroptosis [25, 38, 39]
