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These agents are safe for long-term use during GLP-1 therapy and address the underlying problemhard, slow-moving stoolrather than forcing contractions
A 46 week washout period allows receptor upregulation back to baseline
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The present study shows that exercise induces an increase in plasma CO levels, and this could mean that this defence mechanism has been activated by the increase in exercise-associated ROS and proinflammatory molecules, such as NO
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