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The idea is to provide just enough UV stimulus to activate the MT-1-primed melanocytes without causing burning or significant DNA damage
The MAS comprises MDH1/2, GOT1/2, the malate--KG antiporter and the glutamate-aspartate antiporter, which exchanges mitochondrial -KG for cytosolic malate that is synthesized from oxaloacetic acid (OAA) by cytosolic MDH (Fig
This mechanism converges with the previously detailed inflammatory mechanisms, particularly those mediated by pro-inflammatory cytokines, and the increase in adiposity, representing a shared pathological link between metabolic dysfunction and skeletal muscle impairment
