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Mechanism: Upstream vs Downstream NAC works upstream by supplying cysteine, letting cells synthesize glutathione in response to their own metabolic demand
To the reporters of the investigation, McGuire was more direct: the compound should not be used by humans. Eric Topol, director of the Scripps Research Translational Institute, was even more straightforward than McGuire: None of [the experimental compounds] are proven. He called it extraordinary that gray market human use was occurring in the absence of adequate clinical trials
Angiogenesis promotion is a theoretical concern for individuals with active or suspected cancer, and TB-500 should not be used by pregnant or breastfeeding individuals
10.1053/j.gastro.2005.12.026 42 GroverM.BernardC
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