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The shortage has ended, but the practice has continued
We thank Daniel Drucker and Anthony Gramolini (Toronto, Canada) and Gary Lopaschuk (Edmonton, Canada) for helpful discussions and Daniel Drucker for providing the Glp1r / mice
A dedicated hepatic impairment PK study (standard for NDA submissions) will likely stratify participants by Child-Pugh class and measure retatrutide area under the curve (AUC) and maximum concentration (Cmax) across impairment groups
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