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All of these drugs control obesity by making people feel less hungry, but Tamara Milder, an endocrinologist with UNSW, told me they also directly improve cardiovascular and kidney health on top of the benefits from weight reduction

Much of the progress with metabolite ratios to date has focused on alterations within a given metabolic pathway, while a relatively limited amount of epidemiological research has explored the relationship between metabolites across pathways

A 2025 RAND survey on GLP-1 use in the United States found that about half of adults on GLP-1 agonists report experiencing nausea

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