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Its function as an antioxidant and determinant of cellular redox potential is crucial both for protection from reactive oxygen species as well as a signaling molecule involved in cellular proliferation, cell cycle regulation, and apoptosis
however, how mutant TDP-43 reduces HO1 level and prevents sulforaphane from activating Nrf2 signalling remains unclear
doi: 10.1002/smll.202309038 56 ODonoghueJFreemanF
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