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Outside that indication, the evidence does not support declaring one a universal winner
Because the combination of CJC-1295 and Ipamorelin utilizes natural physiologic pathways and preserves the negative feedback loop, it does not cause the severe receptor downregulation associated with direct hGH
The mechanism is similar in principle: a solution is injected into the subcutaneous fat layer, and the active ingredients are believed to disrupt the membrane of fat cells so the triglyceride contents can be cleared by the lymphatic system over the following weeks
This selectivity makes Ipamorelin uniquely valuable for isolating GH-specific signalling without confounding adrenal axis effects
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