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Generally, large ions with low charge density (e.g., Ba 2+ ) are strong chaotropic agents (substances capable of breaking the hydrogen bonding network between water molecules) and they can significant hinder hydrophobic interactions, whereas small ions with high charge density (e.g., PO 4 3- ) are highly anti-chaotropic and can substantially promote hydrophobic interactions5

Fleming AM, Burrows CJ (2020) On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics

Originally developed for treating peripheral vascular diseases [75], PTX has shown remarkable pleiotropic effects that extend beyond its primary indication

Liraglutide and resveratrol alleviated cyclosporin A induced nephrotoxicity in rats through improving antioxidant status, apoptosis and pro-inflammatory markers