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A 2021 double-blind RCT by Wahab and colleagues in the International Journal of Dermatology (n=46, 8 weeks, colorimetric melanin index endpoint) found that combined topical plus oral glutathione produced a significantly lower melanin index and L* score versus placebo, with the combination outperforming monotherapy
Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R
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