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Why Semaglutide Works So Well for Weight Loss Semaglutide is a GLP-1 receptor agonist
Rather than stopping entirely and risking the weight regain documented in the STEP 1 extension trial (Wilding et al., Diabetes Obes Metab, 2022), where participants regained two-thirds of lost weight within one year of stopping, a microdose may provide enough GLP-1 receptor activation to maintain the appetite set-point shift
Patients who attempt to apply insulin dosing concepts to semaglutide risk severe dosing errors
Take 1ml daily (1 syringe ) under tongue
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