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The jump from 4 mg to 8 mg retatrutide is the biggest escalation step and commonly produces the most significant GI effects
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This is in preparation for the mixing water to be added to the vial, to avoid pressure in the vial, that wont allow you to add much water to it
The pivotal Phase 2 trial (NCT04881760), published in The New England Journal of Medicine (Jastreboff et al., 2023), enrolled 338 adults with BMI 30 or higher
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