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As primarily secreted proteins, IGFBPs are released into the extracellular space, where they interact with IGF-1 (Oxvig and Conover, 2023)
Studies have shown that increased intake of vitamin C also increases glutathione levels within red blood cells 3 and white blood cells
Ethics statement The studies involving human participants were reviewed and approved by Ethics Committee of the Anhui Provincial Mental Health Center
The breakdown of oral glutathione in the gut is driven partly by the enzyme gamma-glutamyltransferase, which is why a conventional tablet raises blood glutathione only slightly (Buonocore et al., Oxidative Medicine and Cellular Longevity 2016, PMID 26649136)
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