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The satiety produced by amylin analogues tends to reduce caloric intake without the extreme food aversion that sometimes occurs with high-dose GLP-1 agonists, which can lead to inadequate protein intake and subsequent muscle loss
When administered intramuscularly (arm or buttock), you will have a rapid onset of action and it bypasses GI metabolism as well as provide increased bioavailability
The LEAN trial specifically demonstrated histologic improvement in NASH patients, with resolution of NASH in 39% of liraglutide-treated patients
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