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Increased expression and activity of P-gp in ECs and BCRP in reactive astrocytes are evident in the motor cortex of ALS patients, potentially contributing to multidrug resistance [246]
Doctors who Science News talked to for this story emphasized the significance of the recent MASH progress, calling this era in the field a watershed moment, and the more than a dozen new medications in development a tidal wave. Rezdiffra may have been the first drug FDA-approved for MASH, but in the next two to three years, Su says, there will be many more
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