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The Global GLP-1 Revolution and Its Price Tag In less than a decade, GLP-1 drugs (medicines that mimic a natural gut hormone to help control blood sugar and appetite) have moved from niche diabetes treatments to global blockbusters for diabetes, obesity, and heart protection

What the Clinical Evidence Shows While large-scale randomized controlled trials specifically measuring testosterone as a primary endpoint in tirzepatide users are still emerging, the available evidence is encouraging: The SURMOUNT trials demonstrated average weight losses of 15-22.5% of body weight, a degree of fat reduction strongly associated with testosterone recovery in men with obesity-related hypogonadism (Jastreboff et al., 2022, NEJM )

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