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Source: Evaluate Pharma, World Obesity Federation, Putnam Analysis Q2, 2025 Unmet Needs and Potential Differentiation Levers Despite extraordinary promise, there are still unmet needs that biopharma companies can target to address: GI Tolerability The most common GI adverse events (nausea, vomiting, and diarrhea) often lead to therapy discontinuation

The process mirrors the TSA experience

This helps increase fullness while keeping carbs in check

He added that his surprise doesnt stem from any concerns over the mechanism of action for the two drugs, but rather because orforglipron has not gone through the extensive evaluation of adverse effects since its not approved yet