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A Multi-Center, Open-Label, Phase I Study of Single Agent RG7112: A First in Class p53-MDM2 Antagonist, in Patients with Relapsed/Refractory Acute Myeloid and Lymphoid Leukemias (AML/ALL) and Refractory Chronic Lymphocitic Leukemia/Small Cell Lymphocytic Lymphomas (CLL/SCLL)

This carnitine deficiency effectively starves the cells of their primary fuel source, locking the patient in a state of perpetual energetic depletion that cannot be resolved simply by resting or eating more calories

"And through a wonderful series of discussions with the sponsor, with a very compelling reason, we decided to take eventscardiovascular death and worsening heart failure eventsand take it out of the composite and have it as a standalone end point." Packer added that worsening heart failure events were adjudicated by a blinded end point committee and defined as worsening symptoms of heart failure requiring either hospitalization, urgent intravenous drug therapy, or oral diuretic intensification

Pathology Reports: Lab results from tissue removed during surgery (e.g., gallbladder or intestinal tissue)