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Single, double and triple knockout mutants for DHAR have been reported (Noshi et al
Hyperglycemic environments are characterized by abnormal mitochondrial dynamics, a tendency for mitochondria to fission rather than to fuse, excessive mitochondrial fission, reduced mitochondrial fusion, and excessive ROS production in different cell types under hyperglycemic conditions, ultimately leading to mitochondrial dysfunction [93, 94]
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the thiol group of cysteine is able to donate a reducing equivalent (H + + e " ) to other unstable molecules, such as reactive oxygen species
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