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It fuels cellular energy, supports DNA repair, and plays a crucial role in metabolic health

Key Areas of Research: Circadian: Delta-wave, REM modulation, entrainment Neuroendocrine: Corticosterone, ACTH, HPA axis Signaling: GABAergic, serotonergic, dopaminergic Neuronal: Oxidative stress, calcium dynamics, viability Together, these findings demonstrate DSIPs multifaceted actions across circadian, endocrine, and neuronal signaling systems

To ask whether other -KG-producing enzymes regulate the YBX1AMPK axis similarly to GDH1, we further knocked down GPT2 and/or GOT2 in Huh7 and H1299 cells and found that GPT2 and GOT2 single or double depletion minimally impacted YBX1 and AMPK expression and intracellular -KG abundance (Supplementary Fig

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