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Cosmetic effects like Ozempic face (a thinner, gaunt appearance from rapid fat loss in the face) and temporary hair shedding have also been reported

Secreted HMGB1 and ATP levels were measured using the Mouse HMGB1 ELISA Kit (#PH406, Beyotime) and the ATP Assay Kit (#S0027, Beyotime), respectively, following the manufacturers instructions

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However, the evident activity of SA--gal, caused by H 2 O 2 , was remarkably reduced by silencing p53 with p53 siRNA, silencing progerin with progerin siRNA, or silencing p21 with p21 siRNA (Fig