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Glutathione peroxidase activity (U/L) = (Conc
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Bidirectional signaling further reinforces this crosstalk: tumor-cellderived lactate, HMGB1, prostaglandins, and oxidized lipids polarize macrophages toward either ferroptosis-promoting (M1-like) or ferroptosis-restraining (M2-like) states
This selectivity allows it to stimulate growth hormone release while maintaining balanced endocrine signalling
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