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Some individuals experience temporary fatigue or mild insomnia, especially during early treatment, while others sleep better due to weight loss and improved metabolic health
Obesity is associated with elevated intracranial pressure through increased cerebrospinal fluid production driven by high insulin levels and elevated intra-abdominal pressure transmitted upward
Furthermore, an inverse relationship between plasma 25(OH)D3 and depression symptoms and major depressive disorder (MDD) was identified in cross-sectional and cohort studies [20,21,22]
While this is an extremely rare condition, it represents an important contraindication specific to the methylcobalamin component of this formulation
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