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A vial labeled as 5mg of semaglutide sodium contains slightly less active semaglutide by weight than a vial labeled as 5mg semaglutide base

This explains why topical applications achieve far lower tissue concentrations than injection

[1] The use of steroid injections is controversial

This explains anecdotal success with: Sciatic nerve recovery Post-surgical nerve pain Numbness, tingling, or radiating nerve issues from disc injury BPC-157 promoted peripheral nerve regeneration and protected against neuroinflammation-induced degeneration via modulation of IL-6 and NGF expression. Miklic et al., Neuroscience Letters 5