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10.1093/nar/gkx194 165 WagnerH.ChengJ

The published phase 2 obesity trial enrolled 338 adults and reported dose-dependent body-weight changes over 48 weeks, alongside gastrointestinal adverse events and increases in heart rate that require continued study [3]

In a Phase III trial in patients 6 to 12 years, the drugs pharmacokinetic and pharmacodynamic profiles were consistent with that seen in previous studies, according to AstraZeneca

The new results suggest but dont prove that the weight-loss medications may be able to target the underlying source of cravings that affect the more than 48 million Americans with substance use disorders