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NICE recommends disease-modifying antirheumatic drugs (DMARDs) such as methotrexate as first-line treatment, with biologic therapies (TNF inhibitors, IL-6 inhibitors) or JAK inhibitors for patients with inadequate response

WD increased weight gain and plasma leptin levels and reduced PSD95 in the amygdala in both sexes, whereas GE2 treatment induced weight loss, elevated plasma PYY levels, and improved associative learning in both sexes

Severe hypokalaemia (low blood potassium) is rare but can develop in some cases, particularly in severe megaloblastic anaemia or in patients taking certain medications such as diuretics

Still, there are cases where B12 injections are the better bet