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Role of oncometabolites in tumor progression As mentioned above, among the hallmarks of cancers, metabolic alterations are emerging as one of the most intriguing and complex therapeutic targets [21, 22] due to the strict connections of the different metabolic pathways and the capacity of cancer cells to adapt their energetic requirements on nutrient availability and microenvironmental changes

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Hair shedding is tied to rapid, large weight loss rather than a unique drug toxicity

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Riboflavin stimulates fat metabolism, accelerating fat breakdown into a fatty acid

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Ann Neurol 1994;35:482-7

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