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Activated Protein C (APC), which cleaves protease-activated receptor 1 in brain endothelium and targets Rac1 GTPase, strengthens the BBB via the -arrestin-2-dependent biased signaling pathway [285]
Broux et al., In vitro BBB models have been crucial to establish links between inflammatory immune components and BBB degradation
Several commercial laboratories offer telomere length analysis through blood samples
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