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Longer half-life means more drug overlap when you inject early

They can be used to treat diabetes mellitus type 2

In patients with #SHTG and metabolic dysfunction-associated steatotic liver disease (#MASLD), just 4 weeks of treatment produced: Up to 57% reductions in triglycerides Over 50% reductions in remnant cholesterol a key driver of residual cardiovascular risk with no changes in LDL-C or HDL-C ~30% improvements in liver fat A favorable safety and tolerability profile Notably, in patients with the most severely elevated triglycerides (500 mg/dL) those at highest risk for acute pancreatitis both doses produced consistent ~62% reductions, reinforcing the strength of this signal in the patients who need it most

Four proline residues, including an unusual triple-proline sequence, confer resistance to enzymatic degradation