"These drugs have the potential to bring about substantial weight loss, particularly in the first year," says Juan Franco, co-lead researcher from Heinrich Heine University Dsseldorf, Germany
Clinical studies have shown that semaglutide can reduce energy intake in controlled settings, with significant variability between individuals
injection site reactions (redness, swelling, localised pruritus) are common, affecting 110% of patients, whilst generalised itching and urticaria are uncommon, affecting 0.11%, and may indicate a hypersensitivity reaction
Furthermore, inflammatory and fibrotic mediators can directly modify atrial electrophysiology and enhance AF susceptibilityfor instance, by regulating calcium homeostasis and connexins, which are associated with AF triggers and slow atrial conduction (106, 107)