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Commonly reported issues include: Mild irritation or redness at the injection site Headaches Fatigue Nausea These effects tend to resolve quickly and do not usually require medical intervention
Dosing information Usual Adult Dose for Pernicious Anemia: Initial dose: 100 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 days If clinical improvement and reticulocyte response is seen from the above dosing: 100 mcg every other day for 7 doses, then: 100 mcg every 3 to 4 days for 2 to 3 weeks, then: Maintenance dose: 100 to 1000 mcg monthly Duration of therapy: Life Comments: Administer concomitant folic acid if needed
3-Month Supply (30 ml Vial, 30 at 1,000 mcg/mL)
Here, homocysteine is converted back into methionine independently of B12 and the folate cycle, with trimethylglycine (TMG, also called betaine = methylated choline) functioning as a cofactor of the enzyme betaine homocysteine methyltransferase (BHMT)
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