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Due to species differences, dulaglutide (a human GLP-1 variant fused with a human IgG4 variant) showed a longer t 1/2 in humans than in monkeys (120 h versus 51.6 3.2 h, respectively) and further research will be required to determine whether Exendin-4-Fc also has a longer t 1/2 in humans
For steady-state BE studies (if applicable): AUC and Cmax: 90% CI within 80.00125.00% Cmin: Test product must not be less than 80% of reference
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