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In Phase 2, retatrutide produced mean weight loss of roughly 24% at 48 weeks at the highest dose, while tirzepatide achieved about 2022% in the SURMOUNT obesity trials cross-trial comparisons should be interpreted cautiously
Often possible, but dehydration from GI side effects can worsen kidney function, so monitoring and hydration are important
The possible causes of semaglutide headaches should therefore be considered together with symptom timing and accompanying signs
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