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Interventions Participants consumed one sachet of either i) L-Carnitine-combination (1500 mg given as 2200 mg Carnipure tartrate (Lonza, Switzerland), 2000 mg L-leucine, 3000 mg creatine monohydrate, and 0.01 mg (400 IU) of vitamin-D3), ii) L-Carnitine (1500 mg given as 2200 mg Carnipure tartrate (Lonza, Switzerland)), or iii) appearance- and taste-matched placebo each day, in the morning with breakfast

We used a random effects model, with odds ratio and mean difference computed for binary and continuous outcomes, respectively

Primer sequences for ChIP assay are provided in Supplementary Table 3

Pigmented spots can darken as overall tone rises