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Most of these agents act as inhibitors to affect downstream pro-inflammatory cytokines by blocking the corresponding targets, reducing symptoms and pain ( Figure 1 )
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Evidence ranges from promising to preliminary depending on the peptide and indication
Weight loss : Retatrutide showed 28.7% at 68 weeks (Phase 3 TRIUMPH-4) versus CagriSema's 20.4% at 68 weeks (Phase 3 REDEFINE 1), though cross-trial comparisons are limited
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