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According to their respective PK profiles, exenatide BID and lixisenatide can be categorized as short-acting agents (each has a half-life of 35 h) compared with the long-acting agents liraglutide, exenatide LAR, albiglutide, and dulaglutide, which have half-lives ranging from 12 h to several days [16]

Anyone with pancreatitis history, severe dehydration, or electrolyte imbalances should also abstain, as alcohol worsens these conditions

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And oftentimes that is doing both estrogen and progesterone and in some cases testosterone if warranted