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Side effects are rare and typically limited to mild, transient skin irritation or redness at the application site, particularly with higher concentrations
Through metabolomic analysis of T2DM and DKD patients, they found that N-acetylaspartate, L-valine, betaine, isoleucine, asparagine, and L-methionine were significantly elevated in DKD patients, with high levels of L-leucine and isoleucine significantly associated with rapid estimated glomerular filtration rate (eGFR) decline
In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions.3 10 In rodents, doses as low as 0.5mg/kg were found to be effective in delivering these anti-pain effects.25 In a 70kg human, an equivalent dose would be around 5.6mg, though thats likely higher than necessary: pharmaceutical-grade GHK-Cu normally ranges from 0.5 mg to 2.5mg per injection
Don't kiss someone or perform oral sex on them if they have visible sores on or around their mouth or genitals
