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Acute administration of semaglutide, tirzepatide, and retatrutide each attenuated alcohol discrimination across multiple doses, suggesting that blunting or altering subjective alcohol effects could be a common target of this drug class
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The absorption-enhancing action of SNAC on semaglutide was found to require concentrations in the millimolar range, as reflected by a significant increase in the apparent permeability coefficient of semaglutide across gastric epithelial cell monolayers in the presence of 80 mM SNAC
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