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Patients must be at least 18 years old and meet one of the following clinical requirements when GLP-1 therapy begins: A body mass index, or BMI, of 35 or higher A BMI between 30 and 34.99 with at least one qualifying health condition A BMI between 27 and 29.99 with at least one qualifying higher-risk health condition For someone with a BMI between 30 and 34.99, qualifying conditions may include heart failure with preserved ejection fraction, uncontrolled high blood pressure, stage 3a or higher chronic kidney disease, prediabetes, a previous heart attack or stroke, or symptomatic peripheral artery disease

I found a systematic review of the evidence on BPC-157 that was published last year by some reputable researchers

Natural GLP-1 Boosters Certain foods and herbs can naturally boost GLP-1 secretion or mimic its effects

Elevated serum B12 levels discovered incidentally on blood tests are often asymptomatic