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Hum Reprod Update 19 , 232243, (2013)
Specifically, hypoxia-induced glycolysis in PDAC cells provokes the lactylation of lysine 34 on NUSAP1, a spindle microtubule regulator, which enhances its expression by hindering its degradation, consequently establishing an NUSAP1-LDHA-glycolysis-lactate feedforward loop and facilitating metastasis in PDAC
It may present with pain, burning, watering eyes and difficulty seeing
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