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Tesofensine lowers body weight mainly by reducing appetite, increasing satiety, and enhancing energy expenditure, making it a promising candidate for the pharmacological treatment of obesity 1-4 .

Understanding the evidence, safety considerations, and lack of proven synergistic benefit is essential for informed clinical decision-making when patients consider combining these treatments

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The reported adverse reactions following parenteral administration of vitamin B12 include: Generalized : Anaphylaxis and death Cardiovascular : Pulmonary edema and congestive cardiac/heart failure during early treatment