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HUBERMAN: Within the milieu of the gut, you have a lot of turnover of cells

Hojo T, Skarzynski DJ, Okuda K

by binding to Apaf-1, HSP70 induces conformational changes that mask the procaspase-9-binding site on Apaf-1, thereby preventing procaspase-9 recruitment to the apoptosome and inhibiting downstream caspase activation (Beere et al., 2000)