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Since semaglutide already impairs the normal B12 absorption pathway, using a form that requires fewer metabolic steps to become active reduces the total burden on an already stressed system

Low grade inflammation common to maternal obesity may induce effects in humans more similar to the inflammation animal models, leading to a higher rate of maternal -fetal transfer and direct effects in the fetus

Harder stools Increased bloating More abdominal discomfort Feeling overly full after eating Less frequent bowel motions Some people do perfectly well on GLP-1s with the right support, but others find constipation becomes significantly worse especially if hydration, food intake or fibre balance arent carefully managed

[1] Establishing realistic expectations for long-term tirzepatide treatment is essential for patient satisfaction and sustained adherence