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Over up to seven years of follow-up, those treated with semaglutide or tirzepatide had a 37% lower risk of developing dementia (hazard ratio [HR] 0.63, 95% CI 0.500.81), a 19% lower risk of stroke (HR 0.81, 95% CI 0.700.93), and a 30% lower risk of all-cause mortality (HR 0.70, 95% CI 0.630.78), compared to those on other antidiabetic drugs
43 Therefore, discontinuation of treatmentprimarily due to cost and access limitationsremains the major barrier to the widespread and sustainable use of these agents
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The FDA crackdown aims to address safety concerns associated with compounded medications, which are not subject to the same rigorous approval process as their branded counterparts
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